EWS-FLI1 employs an E2F switch to drive target gene expression
نویسندگان
چکیده
منابع مشابه
EWS-FLI1 employs an E2F switch to drive target gene expression
Cell cycle progression is orchestrated by E2F factors. We previously reported that in ETS-driven cancers of the bone and prostate, activating E2F3 cooperates with ETS on target promoters. The mechanism of target co-regulation remained unknown. Using RNAi and time-resolved chromatin-immunoprecipitation in Ewing sarcoma we report replacement of E2F3/pRB by constitutively expressed repressive E2F4...
متن کاملGene expression response to EWS–FLI1 in mouse embryonic cartilage
Ewing's sarcoma is a rare bone tumor that affects children and adolescents. We have recently succeeded to induce Ewing's sarcoma-like small round cell tumor in mice by expression of EWS-ETS fusion genes in murine embryonic osteochondrogenic progenitors. The Ewing's sarcoma precursors are enriched in embryonic superficial zone (eSZ) cells of long bone. To get insights into the mechanisms of Ewin...
متن کاملEWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma
Ewing sarcoma is an aggressive bone malignancy that affect children and young adults. Ewing sarcoma is the second most common primary bone malignancy in pediatric patients. Although significant progress has been made in the treatment of Ewing sarcoma since it was first described in the 1920s, in the last decade survival rates have remained unacceptably invariable, thus pointing to the need for ...
متن کاملogenic Partnerships: EWS-FLI1 Protein Interactions
Download eted therapy for cancer, which is specifically directed toward the cancer without any potential for outside of controlling the tumor, is a gold standard for treatment. Ewing's sarcoma contains the tial target EWS-FLI1, as a result of a pathognomonic chromosomal translocation. The EWS-FLI1 protein includes the EWS domain, a potent transcriptional activator alongside the highly conserved...
متن کاملPhosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage.
In Ewing's sarcomas, chromosomal translocations cause the N-terminal domain of the EWS (Ewing's sarcoma protein) to fuse with the DNA-binding domains of the Ets (E26 transformation-specific) family of transcription factors. Here we show that EWS and EWS-Fli1 (Friend leukaemia virus integration 1), the fusion most frequently found in Ewing's sarcomas, become phosphorylated at Thr(79) in response...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2015
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkv123